William Ellison

Zollinger-Ellison syndrome

Since Zollinger and Ellison described in 1955 a pathological entity consisting of multiple recurrent peptic ulcerations, gastric hypersecretion, and islet cell tumours of the pancreas, several reports have been published dealing with the clinical and biological aspects of this new syndrome (Priest and Alexander, 1957;Summerskill, 1959; Gregory,Tracy, French, and Sircus, 1960; Grossman, Tracy, a...

Zollinger-Ellison Syndrome

Epidemiology The incidence of gastrinomas is 0.5-2/million population/year. [3] 20-30% of patients have ZES as part of MEN1, an autosomal dominant disorder. [4] Mean age of presentation is around 40, being younger in MEN1 patients than sporadic cases. Only about 3% present before age 20 and 7% after age 60. Gastrinomas are the most common functioning tumour of the pancreas. In addition to secre...

[Zollinger-Ellison syndrome].

The preoperative localization of gastrinomas often fails despite all modern imaging methods. Therefore, after biochemical confirmation of the diagnosis and exclusion of diffuse metastases, a meticulous surgical exploration including intraoperative ultrasound (IOUS) and duodenal exploration after duodenotomy should be performed. The experienced surgeon will be able to identify more than 90% of t...

[Zollinger-Ellison syndrome].

Medical management of patients with Zollinger-Ellison syndrome has considerably evolved since initial reports in 1955 and especially over the last decade. Control of gastric hypersecretion by effective antisecretory drugs, accurate localization and staging of the tumoral process by modern medical imaging techniques as well as progress in surgical skill undoubtedly account for higher rates of ga...

Dr Ian Ellison -